منابع مشابه
Silent RNAs express themselves
R NA molecules stowed in cytoplasmic granules are generally thought to be silent. But a protein mutated in some amyotrophic lateral sclerosis (ALS) patients forms granules that permit translation of stored RNAs, Yasuda et al. reveal (1). The fi nding identifi es a new mechanism that could contribute to the pathology of the disease and suggests that RNAs in other types of granules also may not b...
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Multi-copy transgenes are poorly expressed in plants, Drosophila and mammals; this repression is relieved by reducing copy number, leading to chromatin remodeling and transcriptional activation. Host defense mechanisms monitor repeated sequences in the genome, modulating their chromatin packaging and functional capabilities.
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In this study, the issue of using Instagram social network by different groups of Iranian women and their interests and desires in publication of photos is investigated. The purpose of the study is to identify the common aspects and differences in women’s lives reflected in their self-expression efforts based on their social characteristics. Therefore, the women were classified into eight...
متن کاملEngineering cis-telomerase RNAs that add telomeric repeats to themselves.
Telomerase is a ribonucleoprotein complex consisting of a protein reverse transcriptase (TERT) and an RNA subunit (TR). Telomerase normally adds telomeric DNA repeats to chromosome ends. Here, we engineer human and Tetrahymena cis-telomerase RNAs, each having a DNA primer covalently linked to its 3' end. We find that cis-telomerase synthesizes DNA with increased repeat addition processivity (RA...
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Heterochromatin is classically perceived to be refractory to transcription because of its compact structure. However, Keller et al (2012) now demonstrated that heterochromatic transcripts can accumulate even when heterochromatin is normally packaged. By tracking down the fate of these heterochromatic RNAs, they revealed a new post-transcriptional mechanism of silencing in heterochromatin that i...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2013
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2035if